Title : The scopolamine model as a pharmacodynamic marker in early drug development.

Pub. Date : 2012 Mar

PMID : 21901320






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1 OBJECTIVE: Preclinical and clinical experiments were designed to examine the utility of the scopolamine-induced cognitive impairment model in predicting pharmacodynamic signals of putatively procognitive compounds, utilizing the acetylcholinesterase inhibitor donepezil for illustration. Donepezil acetylcholinesterase (Cartwright blood group) Homo sapiens