Title : Polymorphisms in genes that regulate cyclosporine metabolism affect cyclosporine blood levels and clinical outcomes in patients who receive allogeneic hematopoietic stem cell transplantation.

Pub. Date : 2012 Jan

PMID : 21896346






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The CYP3A5 +6986AA genotype was associated with a high cyclosporine blood level after transplantation. Cyclosporine cytochrome P450 family 3 subfamily A member 5 Homo sapiens
2 Although the CYP3A5 +6986AA genotype was correlated with a high blood cyclosporine concentration, lack of the MDR1 +1236CC genotype in both the donor and recipient was correlated with less TRM and a longer OS in patients who received allogeneic HSCT. Cyclosporine cytochrome P450 family 3 subfamily A member 5 Homo sapiens