Pub. Date : 2011
PMID : 21895401
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin induces apoptosis of lung cancer cells through activating JNK/p38 MAPK pathway and GADD153. | Metformin | DNA damage inducible transcript 3 | Homo sapiens |
| 2 | We also found that metformin treatment can activate AMP-activated protein kinase, JNK/p38 MAPK signaling pathway and caspases, as well as upregulate the expression of growth arrest and DNA damage inducible gene 153 (GADD153). | Metformin | DNA damage inducible transcript 3 | Homo sapiens |
| 3 | We also found that metformin treatment can activate AMP-activated protein kinase, JNK/p38 MAPK signaling pathway and caspases, as well as upregulate the expression of growth arrest and DNA damage inducible gene 153 (GADD153). | Metformin | DNA damage inducible transcript 3 | Homo sapiens |
| 4 | Either blockade of JNK/p38 MAPK pathway or knockdown of GADD153 gene abrogated the apoptosis-inducing effect of metformin. | Metformin | DNA damage inducible transcript 3 | Homo sapiens |
| 5 | Taken together, our data suggest that metformin inhibits the growth of lung cancer cells and induces apoptosis through activating JNK/p38 MAPK pathway and GADD153. | Metformin | DNA damage inducible transcript 3 | Homo sapiens |