Title : Spinal glycinergic and GABAergic neurons expressing C-fos after capsaicin stimulation are increased in rats with contralateral neuropathic pain.

Pub. Date : 2011 Nov 24

PMID : 21889971






3 Functional Relationships(s)
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1 Spinal glycinergic and GABAergic neurons expressing C-fos after capsaicin stimulation are increased in rats with contralateral neuropathic pain. Capsaicin Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 We have investigated this phenomenon by studying the activation pattern (using C-fos labeling) of spinal glycinergic and GABAergic (Gly/GABA) neurons after capsaicin injection in the ipsilateral hind paw of rats that were preconditioned with an acute or chronic pain stimulus in the contralateral hind paw or rats that were not preconditioned (control). Capsaicin Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 We found that after capsaicin injection in rats preconditioned with CFA inflammation (4 days), sham-SNI or with SNI neuropathic pain, the numbers (27 +- 3, 21 +- 2, and 21 +- 2, respectively) and percentages (55% +- 4, 43% +- 2, and 42% +- 2, respectively) of C-fos activated neurons that were Gly/GABA increased significantly as compared with control (10 +- 1 and 25% +- 2). Capsaicin Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus