Title : Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray.

Pub. Date : 2013 Nov

PMID : 21887816






2 Functional Relationships(s)
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1 Comparison of genome-wide microarray expression profiles between a nonmutagenic and a mutagenic PAH-treated group revealed that xenobiotic response genes such as CYP1B1 were commonly upregulated in two groups and that DNA damage induced genes, especially p53-downstream genes such as p21 (CDKN1A) were upregulated only in the mutagenic PAH-treated group. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 Comparison of genome-wide microarray expression profiles between a nonmutagenic and a mutagenic PAH-treated group revealed that xenobiotic response genes such as CYP1B1 were commonly upregulated in two groups and that DNA damage induced genes, especially p53-downstream genes such as p21 (CDKN1A) were upregulated only in the mutagenic PAH-treated group. Polycyclic Aromatic Hydrocarbons cytochrome P450 family 1 subfamily B member 1 Homo sapiens