Title : Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: a pilot study.

Pub. Date : 2012 Apr 1

PMID : 21887680






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Methotrexate toxicity was increased in variants of MTHFR c.1298A>C p.Glu(429)Ala (P = .038), ABCB1 c.3435T>C Ile(145)Ile (P = .027), and ABCC2 c.3563T>A p.Val(1188)Glu (P = .028). Methotrexate ATP binding cassette subfamily B member 1 Homo sapiens