Pub. Date : 2011 Nov 1
PMID : 21884783
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase. | Sulfhydryl Compounds | myeloperoxidase | Homo sapiens |
| 2 | We hypothesized that smokers would have a high level of thiocyanate (SCN(-)), a preferred substrate for MPO, which in turn would predispose to thiol oxidation, an established independent risk factor for atherosclerosis. | Sulfhydryl Compounds | myeloperoxidase | Homo sapiens |
| 3 | In this study it is shown that on exposure to MPO/H(2)O(2), thiols on plasma proteins from nonsmokers were increasingly oxidized with increasing added SCN(-) concentrations. | Sulfhydryl Compounds | myeloperoxidase | Homo sapiens |
| 4 | When plasma from smokers and nonsmokers was exposed to MPO/H(2)O(2)-stimulated oxidation, a strong positive correlation (r=0.8139, P<0.0001) between the extent of thiol oxidation and the plasma SCN(-) concentrations was observed. | Sulfhydryl Compounds | myeloperoxidase | Homo sapiens |
| 5 | These data indicate that plasma SCN(-) levels are a key determinant of the extent of thiol oxidation on plasma proteins induced by MPO, and implicate HOSCN as an important mediator of inflammation-induced oxidative damage to proteins in smokers. | Sulfhydryl Compounds | myeloperoxidase | Homo sapiens |