Title : Glucocorticoid-induced immunoglobulin E synthesis by peripheral blood mononuclear cells from allergic and nonallergic subjects.

Pub. Date : 2011 Sep

PMID : 21875545






3 Functional Relationships(s)
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1 OBJECTIVE: We aimed to compare the effect of GCS (budesonide) on interleukin (IL)-4-driven IgE production in vitro in allergic and non allergic subjects and assess the engagement of intracellular mechanisms. Budesonide interleukin 4 Homo sapiens
2 Budesonide significantly increased lymhoplasmocytoid cells percentage in both media-controlled (2.5-fold increase) and IL-4-stimulated PBMCs (2-fold increase). Budesonide interleukin 4 Homo sapiens
3 Added to IL-4 budesonide decreased the percentage of both T cells and CD40L(+) T cells, but strongly increased the percentage of B cells. Budesonide interleukin 4 Homo sapiens