Title : Endothelin-1-induced proliferation is reduced and Ca²⁺ signaling is enhanced in endothelin B-deficient optic nerve head astrocytes.

Pub. Date : 2011 Sep 29

PMID : 21873674






2 Functional Relationships(s)
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1 ET-1-induced ONHA fura-2 ratio increases were significantly greater in TSL ONHAs (by 20% at 10-7 M and by 48% at 10-9 M) compared with WT ONHAs. Fura-2 endothelin 1 Rattus norvegicus
2 ET-1-induced fura-2 ratio increases were blocked after pretreatment with BQ-610 (ETA antagonist) in WT and TSL ONHAs, but not by BQ-788 (ETB antagonist) in WT ONHAs. Fura-2 endothelin 1 Rattus norvegicus