Title : Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma.

Pub. Date : 2012 May

PMID : 21873469






1 Functional Relationships(s)
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1 In nude mice, histamine increased tumour growth (up to 25%) and VEGF expression whereas inhibition of histamine synthesis (by reduction of HDC) ablated the autocrine stimulation of histamine on tumour growth (~80%) and VEGF expression. Histamine vascular endothelial growth factor A Mus musculus