Title : Active ERK1/2 protein interacts with the phosphorylated nuclear constitutive active/androstane receptor (CAR; NR1I3), repressing dephosphorylation and sequestering CAR in the cytoplasm.

Pub. Date : 2011 Oct 14

PMID : 21873423






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here, we have demonstrated that activated ERK1/2 interacts with phosphorylated CAR to repress dephosphorylation of Thr-38. Threonine mitogen-activated protein kinase 3 Homo sapiens
2 Thus, activated ERK1/2 interacts with CAR and represses dephosphorylation of Thr-38, providing a cell signal-regulated mechanism for CAR activation. Threonine mitogen-activated protein kinase 3 Homo sapiens