Title : AMPK induces vascular smooth muscle cell senescence via LKB1 dependent pathway.

Pub. Date : 2011 Sep 16

PMID : 21872575






3 Functional Relationships(s)
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1 Adriamycin progressively increased the mRNA and protein expressions of AMPK. Doxorubicin protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens
2 The phosphorylation levels of LKB1 and acetyl-CoA carboxylase (ACC), the upstream and downstream of AMPK, were dramatically increased by adriamycin stimulation. Doxorubicin protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens
3 Cytosolic translocation of LKB1 by adriamycin could be a mechanism for AMPK activation in senescence. Doxorubicin protein kinase AMP-activated non-catalytic subunit beta 1 Homo sapiens