Title : Genome-wide expression profiling and mutagenesis studies reveal that lipopolysaccharide responsiveness appears to be absolutely dependent on TLR4 and MD-2 expression and is dependent upon intermolecular ionic interactions.

Pub. Date : 2011 Oct 1

PMID : 21865549






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 According to our murine TLR4/MD-2-activation model, the two phosphates on lipid A were predicted to interact extensively with the two positively charged patches on mouse TLR4. Lipid A toll-like receptor 4 Mus musculus
2 According to our murine TLR4/MD-2-activation model, the two phosphates on lipid A were predicted to interact extensively with the two positively charged patches on mouse TLR4. Lipid A toll-like receptor 4 Mus musculus
3 Hence, we concluded that ionic interactions between lipid A and TLR4 are essential for optimal LPS receptor activation. Lipid A toll-like receptor 4 Mus musculus