Pub. Date : 2011 Nov
PMID : 21862689
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme. | Heme | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Furthermore, inactivation of both CYP2B6 WT and C475S by clopidogrel, but not by 2-oxo-clopidogrel, led to the loss of the heme, which accounts for most of the loss of the catalytic activity. | Heme | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Collectively, these results suggest that clopidogrel inactivates CYP2B6 primarily through destruction of the heme, whereas 2-oxo-clopidogrel inactivates CYP2B6 through covalent modification of Cys475. | Heme | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |