Title : Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9.

Pub. Date : 2011 Nov

PMID : 21856742






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Nonetheless, using the specific substrates entacapone and zidovudine (AZT) for UGT1A9 and UGT2B7, respectively, and using an improved ultrafiltration method for measuring drug binding to BSA and to biological membranes, we found that the presence of BSA during the glucuronidation reaction leads to a large increase in the V(max) value of UGT1A9, in addition to lowering its K(m) value. entacapone UDP glucuronosyltransferase family 1 member A9 Homo sapiens