Title : Inhibition of aldose reductase prevents endotoxin-induced inflammation by regulating the arachidonic acid pathway in murine macrophages.

Pub. Date : 2011 Nov 1

PMID : 21856412






1 Functional Relationships(s)
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1 LPS-induced activation of redox-sensitive signaling intermediates such as MAPKs, transcription factor NF-kappaB, and EGR-1, a transcriptional regulator of mPGES-1, which in collaboration with COX-2 leads to the production of PGE2, was also significantly prevented by AR inhibition. Dinoprostone nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus