Title : Exogenous regucalcin stimulates osteoclastogenesis and suppresses osteoblastogenesis through NF-κB activation.

Pub. Date : 2012 Jan

PMID : 21842421






6 Functional Relationships(s)
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1 The capacity of regucalcin to augment RANKL-induced NF-kappaB activity was inhibited by menaquinone-7, a potent NF-kappaB antagonist, while the Erk inhibitor PD98059 and staurosporine had no effect, demonstrating a specific effect on NF-kappaB signaling. vitamin MK 7 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 The capacity of regucalcin to augment RANKL-induced NF-kappaB activity was inhibited by menaquinone-7, a potent NF-kappaB antagonist, while the Erk inhibitor PD98059 and staurosporine had no effect, demonstrating a specific effect on NF-kappaB signaling. vitamin MK 7 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 The capacity of regucalcin to augment RANKL-induced NF-kappaB activity was inhibited by menaquinone-7, a potent NF-kappaB antagonist, while the Erk inhibitor PD98059 and staurosporine had no effect, demonstrating a specific effect on NF-kappaB signaling. vitamin MK 7 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
4 As with NF-kappaB induction in osteoclasts, NF-kappaB activation was abolished by addition of the NF-kappaB antagonist menaquinone-7, but not by PD98059 and staurosporine. vitamin MK 7 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
5 As with NF-kappaB induction in osteoclasts, NF-kappaB activation was abolished by addition of the NF-kappaB antagonist menaquinone-7, but not by PD98059 and staurosporine. vitamin MK 7 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
6 As with NF-kappaB induction in osteoclasts, NF-kappaB activation was abolished by addition of the NF-kappaB antagonist menaquinone-7, but not by PD98059 and staurosporine. vitamin MK 7 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus