Pub. Date : 2011 Oct 1
PMID : 21832879
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metabolic utilization of exogenous pyruvate by mutant p53 (R175H) human melanoma cells promotes survival under glucose depletion. | Glucose | tumor protein p53 | Homo sapiens |
| 2 | Mutant p53 melanoma were resistant to a comparable metabolic restriction, only showing PARP fragmentation when glucose depletion was accompanied by treatment with diphenylene iodonium (DPI), a NADPH oxidase inhibitor of superoxide (O2*-) generation. | Glucose | tumor protein p53 | Homo sapiens |
| 3 | Metabolic utilization and survival under glucose depletion was increased by pyruvate in mutant p53 (R175H) cells. | Glucose | tumor protein p53 | Homo sapiens |
| 4 | Our results show for the first time that melanoma cells harbouring a p53 (R175H) mutation increase: a) survival under glucose depletion, counteracted by NADPH-oxidase modulators like DPI; b) resistance to DPI when supplemented with exogenous pyruvate. | Glucose | tumor protein p53 | Homo sapiens |