Title : Luciferin IPA-based higher throughput human hepatocyte screening assays for CYP3A4 inhibition and induction.

Pub. Date : 2011 Sep

PMID : 21832258






1 Functional Relationships(s)
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1 The non-CYP3A4 inhibitors diethyldithiocarbamate, quercetin, quinidine, sulfaphenazole, ticlopidine, and tranylcypromine were found to have substantially lower (maximum inhibition of <50%) or no apparent inhibitory effects in the HTS assay. Ticlopidine cytochrome P450 family 3 subfamily A member 4 Homo sapiens