Title : Lysophosphatidic acid 5 receptor induces activation of Na(+)/H(+) exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells.

Pub. Date : 2011 Nov

PMID : 21832242






2 Functional Relationships(s)
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1 However, inhibition of apical EGFR, but not basolateral EGFR, abrogated LPA-induced regulation of MEK and NHE3, indicating that LPA(5) selectively activates apical EGFR. lysophosphatidic acid epidermal growth factor receptor Homo sapiens
2 Together, these results unveil a pivotal role of apical EGFR in NHE3 regulation by LPA and show that the RhoA-ROCK-Pyk2 and MEK-ERK pathways converge onto NHE3. lysophosphatidic acid epidermal growth factor receptor Homo sapiens