Title : Multipotent mesenchymal stromal cells increase tPA expression and concomitantly decrease PAI-1 expression in astrocytes through the sonic hedgehog signaling pathway after stroke (in vitro study).

Pub. Date : 2011 Nov

PMID : 21829213






4 Functional Relationships(s)
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1 Inhibiting the Shh signaling pathway with cyclopamine blocked the increase of tPA and the decrease of PAI-1 expression in astrocytes subjected to MSC coculture or recombinant mouse Shh (rm-Shh) treatment. cyclopamine sonic hedgehog Mus musculus
2 Inhibiting the Shh signaling pathway with cyclopamine blocked the increase of tPA and the decrease of PAI-1 expression in astrocytes subjected to MSC coculture or recombinant mouse Shh (rm-Shh) treatment. cyclopamine sonic hedgehog Mus musculus
3 Inhibiting the Shh signaling pathway with cyclopamine blocked the increase of tPA and the decrease of PAI-1 expression in astrocytes subjected to MSC coculture or recombinant mouse Shh (rm-Shh) treatment. cyclopamine sonic hedgehog Mus musculus
4 Both MSCs and rm-Shh decreased the transforming growth factor-beta1 level in astrocytes, and the Shh pathway inhibitor cyclopamine reversed these decreases. cyclopamine sonic hedgehog Mus musculus