Title : A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes.

Pub. Date : 2011 Nov 1

PMID : 21828076






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The PTEN (phosphatase and tensin homolog) phosphatase is unique in mammals in terms of its tumor suppressor activity, exerted by dephosphorylation of the lipid second messenger PIP(3) (phosphatidylinositol 3,4,5-trisphosphate), which activates the phosphoinositide 3-kinase/Akt/mTOR (mammalian target of rapamycin) oncogenic pathway. pip(3) mechanistic target of rapamycin kinase Homo sapiens
2 The PTEN (phosphatase and tensin homolog) phosphatase is unique in mammals in terms of its tumor suppressor activity, exerted by dephosphorylation of the lipid second messenger PIP(3) (phosphatidylinositol 3,4,5-trisphosphate), which activates the phosphoinositide 3-kinase/Akt/mTOR (mammalian target of rapamycin) oncogenic pathway. pip(3) mechanistic target of rapamycin kinase Homo sapiens