Title : In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine.

Pub. Date : 2011 Oct

PMID : 21826677






2 Functional Relationships(s)
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1 In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) enzymes responsible for the oxidative metabolism of loxapine to 8-hydroxyloxapine, 7-hydroxyloxapine, N-desmethylloxapine (amoxapine) and loxapine N-oxide. 8-hydroxyloxapine cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 In vitro studies were conducted to identify the hepatic cytochrome P450 (CYP) enzymes responsible for the oxidative metabolism of loxapine to 8-hydroxyloxapine, 7-hydroxyloxapine, N-desmethylloxapine (amoxapine) and loxapine N-oxide. 8-hydroxyloxapine cytochrome P450 family 4 subfamily F member 3 Homo sapiens