Title : A novel role of andrographolide, an NF-kappa B inhibitor, on inhibition of platelet activation: the pivotal mechanisms of endothelial nitric oxide synthase/cyclic GMP.

Pub. Date : 2011 Dec

PMID : 21822619






2 Functional Relationships(s)
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1 ODQ, an inhibitor of guanylate cyclase, markedly reversed the andrographolide-mediated inhibitory effects on platelet aggregation, p38 MAPK and Akt phosphorylation, and the andrographolide-mediated stimulatory effect on VASP phosphorylation. andrographolide mitogen-activated protein kinase 14 Mus musculus
2 This study demonstrates for the first time that andrographolide possesses a novel role of antiplatelet activity, which may involve the activation of the eNOS-NO/cyclic GMP pathway, resulting in the inhibition of the PI3 kinase/Akt-p38 MAPK and PLCgamma2-PKC cascades, thereby leading to inhibition of platelet aggregation. andrographolide mitogen-activated protein kinase 14 Mus musculus