Pub. Date : 2011 Nov
PMID : 21821736
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Q172H replacement overcomes effects on the metabolism of cyclophosphamide and efavirenz caused by CYP2B6 variant with Arg262. | efavirenz | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | There are a number of reports indicating that CYP2B6*6 (c.516G>T and c.785A>G) is responsible for decreased clearance of efavirenz (EFV), although increased disposition of cyclophosphamide (CPA) in individuals with this polymorphism was observed. | efavirenz | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |