Title : Persistent expression of Nqo1 by p62-mediated Nrf2 activation facilitates p53-dependent mitotic catastrophe.

Pub. Date : 2011 Aug 26

PMID : 21821009






1 Functional Relationships(s)
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1 With prolonged exposure to nocodazole, a microtubule-depolymerizing agent, p62-deficient HCT116 cells exhibited an accumulation of a polyploid population with a limited appearance of apoptotic cells, which was attributable to the attenuated stabilization of p53. Nocodazole tumor protein p53 Homo sapiens