Title : Mechanism of the inhibitory effect of atorvastatin on leptin expression induced by angiotensin II in cultured human coronary artery smooth muscle cells.

Pub. Date : 2012 Jan

PMID : 21806545






3 Functional Relationships(s)
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1 Atorvastatin, SP600125, JNK siRNA (small interfering RNA) and NAC (N-acetylcysteine) completely attenuated the leptin and phospho-JNK protein expression induced by Ang II. pyrazolanthrone angiogenin Homo sapiens
2 Addition of atorvastatin and SP600125 inhibited the phosphorylation of Rac1 induced by Ang II. pyrazolanthrone angiogenin Homo sapiens
3 The gel shift and promoter activity assay showed that Ang II increased AP-1 (activator protein-1)-binding activity and leptin promoter activity, while SP600125, NAC and atorvastatin inhibited the AP-1-binding activity and leptin promoter activity induced by Ang II. pyrazolanthrone angiogenin Homo sapiens