Title : Radix clematidis extract inhibits TPA-induced MMP-9 expression by suppressing NF-κB activation in MCF-7 human breast cancer cells.

Pub. Date : 2011 Sep-Oct

PMID : 21805048






6 Functional Relationships(s)
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1 Results showed that the expression of MMP-9 and cell invasion in response to TPA was increased, whereas TPA-induced MMP-9 expression and cell invasion was decreased by RCE. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
2 Radix clematidis extract inhibits TPA-induced MMP-9 expression by suppressing NF-kappaB activation in MCF-7 human breast cancer cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
3 The purpose of the present study was to investigate the effects of RCE on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
4 The purpose of the present study was to investigate the effects of RCE on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced MMP-9 expression and cell invasion in MCF-7 cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
5 Results showed that the expression of MMP-9 and cell invasion in response to TPA was increased, whereas TPA-induced MMP-9 expression and cell invasion was decreased by RCE. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens
6 Thus, RCE is a potent inhibitor of TPA-induced MMP-9 expression and markedly blocks the NF-kappaB pathway in MCF-7 cells. Tetradecanoylphorbol Acetate matrix metallopeptidase 9 Homo sapiens