Pub. Date : 2011 Oct
PMID : 21803983
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver: the protective role of the Keap1/Nrf2/ARE pathway. | Azathioprine | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Genetic upregulation of the Keap1/Nrf2/ARE pathway, a major cellular regulator of the expression of a network of cytoprotective genes, reduces the incorporation of 6-thioguanine in DNA of both skin and liver following treatment with azathioprine. | Azathioprine | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | Our findings suggest that activation of the Keap1/Nrf2/ARE pathway could reduce the risk for skin cancer in patients receiving long-term azathioprine therapy. | Azathioprine | NFE2 like bZIP transcription factor 2 | Homo sapiens |