Title : Systemic administration of argatroban inhibits protease-activated receptor-1 expression in perihematomal tissue in rats with intracerebral hemorrhage.

Pub. Date : 2011 Oct 10

PMID : 21803126






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1 Our results showed that the levels of PAR-1 protein or PAR-1 mRNA in ICH and TM groups were up-regulated compared to that observed for the sham group; while the levels observed in ICH+Arg group and TM+Arg group were significantly lower than that observed for the ICH group and TM group (P<0.01 or P<0.05). argatroban coagulation factor II Rattus norvegicus
2 Our results showed that the levels of PAR-1 protein or PAR-1 mRNA in ICH and TM groups were up-regulated compared to that observed for the sham group; while the levels observed in ICH+Arg group and TM+Arg group were significantly lower than that observed for the ICH group and TM group (P<0.01 or P<0.05). argatroban coagulation factor II Rattus norvegicus
3 The intraperitoneal administration argatroban also significantly reduced edema in ICH or TM group (P<0.05). argatroban coagulation factor II Rattus norvegicus
4 Our observations suggested that the production of thrombin following ICH play a key role in the up-regulation of PAR-1 and anti-PAR-1 by systemic administration of argatroban, and may be a potential strategy for ICH therapy. argatroban coagulation factor II Rattus norvegicus