Title : Telomerase reverse transcriptase promoter-driven expression of iodine pump genes for targeted radioiodine therapy of malignant glioma cells.

Pub. Date : 2011 Aug

PMID : 21801606






3 Functional Relationships(s)
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1 Non-thyroid cancers can intake radioiodine after transfection of the human sodium iodide symporter (hNIS) gene. Iodine-131 solute carrier family 5 member 5 Homo sapiens
2 These results demonstrated that radioiodine therapy was effective in treating malignant glioma cell lines following induction of tumor-specific iodide intake by the hTERT promoter-directed hNIS expression in vitro. Iodine-131 solute carrier family 5 member 5 Homo sapiens
3 Co-transfected hNIS and hTPO genes can result in increased intake and longer retention of radioiodine. Iodine-131 solute carrier family 5 member 5 Homo sapiens