Title : Cotransfected sodium iodide symporter and human tyroperoxidase genes following human telomerase reverse transcriptase promoter for targeted radioiodine therapy of malignant glioma cells.

Pub. Date : 2011 Aug

PMID : 21797672






2 Functional Relationships(s)
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1 In principle, undifferentiated thyroid cancers as well as nonthyroid cancers can concentrate and, thus, be treated with radioiodine after transfection with the human sodium iodide symporter (hNIS) gene. Iodine-131 solute carrier family 5 member 5 Homo sapiens
2 METHODS: We used hTERT promoter-modulated expression of the hNIS and human thyroperoxidase (hTPO) genes in an experimental model of radioiodine-based treatment of malignant glioma. Iodine-131 solute carrier family 5 member 5 Homo sapiens