Title : Receptor tyrosine kinase inhibitors and cytotoxic drugs affect pleural mesothelioma cell proliferation: insight into EGFR and ERK1/2 as antitumor targets.

Pub. Date : 2011 Nov 15

PMID : 21787763






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The analysis of downstream effectors of EGFR signaling demonstrated that EGF-induced proliferation, reverted by gefitinib, involved ERK1/2 activation, independently from Akt pathway. Gefitinib mitogen-activated protein kinase 3 Homo sapiens
2 Gefitinib inhibits MPM cell growth and survival, preventing EGF-dependent activation of ERK1/2 pathway by blocking EGFR-TK phosphorylation and stabilizing inactive EGFR dimers. Gefitinib mitogen-activated protein kinase 3 Homo sapiens