Title : Glutathione-dependent interaction of heavy metal compounds with multidrug resistance proteins MRP1 and MRP2.

Pub. Date : 2008 Jul

PMID : 21783896






1 Functional Relationships(s)
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1 The data show that (1) CDDP interacts with both MRP1 and MRP2, and GSH appears to play no major role in this process, (2) As(2)O(3) interacts with MRP1 and MRP2 in which process GSH seems to be essential, and (3) HgCl(2) interacts with MRP1 and MRP2, either alone and/or as a metal-GSH complex. Cisplatin ATP binding cassette subfamily C member 2 Canis lupus familiaris