Title : CCN3 suppresses mitogenic signalling and reinstates growth control mechanisms in Chronic Myeloid Leukaemia.

Pub. Date : 2012 Mar

PMID : 21773872






3 Functional Relationships(s)
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1 K562/CCN3 cells exposed to Imatinib (1 muM and 5 muM) showed an increase in events within the subG(0) phase of cell cycle over 96 h and mirrored the enhanced cell kill demonstrated by Annexin staining. Imatinib Mesylate latexin Homo sapiens
2 K562/CCN3 cells exposed to Imatinib (1 muM and 5 muM) showed an increase in events within the subG(0) phase of cell cycle over 96 h and mirrored the enhanced cell kill demonstrated by Annexin staining. Imatinib Mesylate latexin Homo sapiens
3 Wild type K562 cells treated with recombinant human Ccn3 (10 nM) in combination with Imatinib (5 muM) also displayed enhanced cell kill (p = 0.008). Imatinib Mesylate latexin Homo sapiens