Title : Modulation of NK cell autocrine-induced eosinophil chemotaxis by interleukin-15 and vitamin D(3): a possible NK-eosinophil crosstalk via IL-8 in the pathophysiology of allergic rhinitis.

Pub. Date : 2011

PMID : 21765616






3 Functional Relationships(s)
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1 Modulation of NK cell autocrine-induced eosinophil chemotaxis by interleukin-15 and vitamin D(3): a possible NK-eosinophil crosstalk via IL-8 in the pathophysiology of allergic rhinitis. Vitamin D C-X-C motif chemokine ligand 8 Homo sapiens
2 The amount of IL-8 secreted by NK cells was increased by IL-15 treatment from levels of 88.64 +- 21.5 to 178.9 +- 23.6 Pg/mL and was significantly reduced by 10(-6) M vitamin D(3) to levels of 59.2 +- 16.3 Pg/mL. Vitamin D C-X-C motif chemokine ligand 8 Homo sapiens
3 Our results indicate a novel inflammatory crosstalk between NK cells and eosinophils via IL-15/IL-8 axis that can be modulated by vitamin D(3). Vitamin D C-X-C motif chemokine ligand 8 Homo sapiens