Title : HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7.

Pub. Date : 2011 Aug

PMID : 21762915






1 Functional Relationships(s)
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1 Phagocytosis was found to be enhanced by pravastatin, rosuvastatin and simvastatin and cyclodextrin in J774 macrophages, as cellular cholesterol was reduced and expressions of the cholesterol-related genes were modulated, including an increase of ABCA7 mRNA and decrease of ABCA1 mRNA. Simvastatin ATP-binding cassette, sub-family A (ABC1), member 1 Mus musculus