Title : Synthesis of mitochondrial uncoupling protein in brown adipocytes differentiated in cell culture.

Pub. Date : 1990 Dec 25

PMID : 2176208






2 Functional Relationships(s)
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1 In these cells, it was possible, by using norepinephrine, to induce specifically the synthesis of the UCP but not of F1-ATPase or cytochrome oxidase. Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
2 The maximal response was observed at 0.1 microM norepinephrine and the synthesis of UCP remained activated for at least 24 h. Detailed analysis revealed a major role of the beta-adrenergic receptors and elevated intracellular concentration of cAMP in stimulation of UCP synthesis. Norepinephrine uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus