Title : 2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells.

Pub. Date : 2010 Jun

PMID : 21761355






1 Functional Relationships(s)
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1 Instead, we demonstrate that by selectively antagonizing ERK1/2 signaling in breast cancer cells, 2ME limits the transactivation potential of ligand-bound PR and inhibits the expression of endogenous progesterone targets, such as TF and signal transducer and activator of transcription 5. Progesterone mitogen-activated protein kinase 3 Homo sapiens