Title : Eicosanoids, β-cell function, and diabetes.

Pub. Date : 2011 Aug

PMID : 21757024






2 Functional Relationships(s)
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1 Arachidonic acid (AA) is metabolized by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes into eicosanoids, which are involved in diverse diseases, including type 1 and type 2 diabetes. Eicosanoids cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 A recent publication has demonstrated that stabilizing the levels of epoxyeicosatrienoic acids (EETs), CYP eicosanoids, by inhibiting or deleting soluble epoxide hydrolase (sEH) improves beta-cell function and reduces beta-cell apoptosis in diabetes. Eicosanoids cytochrome P450 family 4 subfamily F member 3 Homo sapiens