Pub. Date : 2011 Sep
PMID : 21753749
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vivo CYP3A activity is significantly lower in cyclosporine-treated as compared with tacrolimus-treated renal allograft recipients. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In vitro studies have identified cyclosporine and tacrolimus as CYP3A inhibitors. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | This implies that in vivo hepatic and first-pass CYP3A activities are significantly lower in patients receiving cyclosporine than in those receiving tacrolimus, indicating that, at the doses generally used in clinical practice, cyclosporine is the stronger of the two with respect to CYP3A inhibition. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | This implies that in vivo hepatic and first-pass CYP3A activities are significantly lower in patients receiving cyclosporine than in those receiving tacrolimus, indicating that, at the doses generally used in clinical practice, cyclosporine is the stronger of the two with respect to CYP3A inhibition. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | This implies that in vivo hepatic and first-pass CYP3A activities are significantly lower in patients receiving cyclosporine than in those receiving tacrolimus, indicating that, at the doses generally used in clinical practice, cyclosporine is the stronger of the two with respect to CYP3A inhibition. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | This implies that in vivo hepatic and first-pass CYP3A activities are significantly lower in patients receiving cyclosporine than in those receiving tacrolimus, indicating that, at the doses generally used in clinical practice, cyclosporine is the stronger of the two with respect to CYP3A inhibition. | Cyclosporine | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |