Title : Bioactive sulfoximines: syntheses and properties of Vioxx analogs.

Pub. Date : 2011 Aug 15

PMID : 21752640






1 Functional Relationships(s)
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1 Interesting data have been obtained for 2a, which shows a selective COX-2 inhibition (albeit not as strong as Vioxx itself) exhibiting reduced hERG activity compare to the parent sulfone Vioxx (1). rofecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens