Title : The T/NK cell co-stimulatory molecule SECTM1 is an IFN "early response gene" that is negatively regulated by LPS in human monocytic cells.

Pub. Date : 2011 Dec

PMID : 21749909






2 Functional Relationships(s)
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1 Co-treatment of MM6 cells with IFN-gamma and cycloheximide caused a superinduction of SECTM1 mRNA expression while cycloheximide alone had no effect, illustrating that de novo protein synthesis is not required for IFN-gamma enhanced expression of SECTM1 mRNA, a characteristic of IFN early response genes. Cycloheximide interferon gamma Homo sapiens
2 Co-treatment of MM6 cells with IFN-gamma and cycloheximide caused a superinduction of SECTM1 mRNA expression while cycloheximide alone had no effect, illustrating that de novo protein synthesis is not required for IFN-gamma enhanced expression of SECTM1 mRNA, a characteristic of IFN early response genes. Cycloheximide interferon gamma Homo sapiens