Title : Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus.

Pub. Date : 2011 Jul 26

PMID : 21747057






3 Functional Relationships(s)
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1 In cultured human aortic endothelial cells exposed to 30 mmol/L glucose, we observed a similar loss of mitochondrial networks and increased expression of Fis1 and dynamin-related protein-1 (Drp1), proteins required for mitochondrial fission. Glucose dynamin 1 like Homo sapiens
2 In cultured human aortic endothelial cells exposed to 30 mmol/L glucose, we observed a similar loss of mitochondrial networks and increased expression of Fis1 and dynamin-related protein-1 (Drp1), proteins required for mitochondrial fission. Glucose dynamin 1 like Homo sapiens
3 Silencing Fis1 or Drp1 expression with siRNA blunted high glucose-induced alterations in mitochondrial networks, reactive oxygen species production, endothelial nitric oxide synthase activation, and cGMP production. Glucose dynamin 1 like Homo sapiens