Pub. Date : 2011 Sep 7
PMID : 21747048
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Genetic variations in the CYP2A6 nicotine metabolic gene and the CHRNA5-CHRNA3-CHRNB4 (CHRNA5-A3-B4) nicotinic gene cluster have been independently associated with lung cancer. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 2 | Cigarette consumption (P < .001) and nicotine dependence (P = .036) were the highest in the combined CYP2A6 normal metabolizers and CHRNA5-A3-B4 AA (tag single-nucleotide polymorphism rs1051730 G>A) risk group. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |
| 3 | Variation in CYP2A6 and CHRNA5-A3-B4 was independently and additively associated with increased cigarette consumption, nicotine dependence, and lung cancer risk. | Nicotine | cytochrome P450 family 2 subfamily A member 6 | Homo sapiens |