Pub. Date : 2011 Oct
PMID : 21743969
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Notch-1 activation-dependent p53 restoration contributes to resveratrol-induced apoptosis in glioblastoma cells. | Resveratrol | tumor protein p53 | Homo sapiens |
| 2 | We demonstrated that resveratrol strongly suppressed cell growth and induced apoptosis in A172 and T98G glioblastoma cells, which have low active Notch-1 expression and a heterozygous p53 mutation. | Resveratrol | tumor protein p53 | Homo sapiens |
| 3 | Our results suggest that resveratrol significantly activates intracellular Notch-1 and restores wild-type p53 expression in a time-dependent manner. | Resveratrol | tumor protein p53 | Homo sapiens |
| 4 | Moreover, simultaneous treatment with resveratrol and a Notch-1 inhibitor (MRK-003) partially attenuated the apoptosis and completely blocked the activation of Notch-1 and the increase in wild-type p53. | Resveratrol | tumor protein p53 | Homo sapiens |