Title : Acetyl tributyl citrate, the most widely used phthalate substitute plasticizer, induces cytochrome p450 3a through steroid and xenobiotic receptor.

Pub. Date : 2011 Oct

PMID : 21742782






3 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Steroid and xenobiotic receptor (SXR) is activated by endogenous and exogenous chemicals including steroids, bile acids, and prescription drugs. Steroids nuclear receptor subfamily 1 group I member 2 Homo sapiens
2 Steroid and xenobiotic receptor (SXR) is activated by endogenous and exogenous chemicals including steroids, bile acids, and prescription drugs. Steroids nuclear receptor subfamily 1 group I member 2 Homo sapiens
3 SXR is highly expressed in the liver and intestine, where it regulates cytochrome P450 3A4 (CYP3A4), which in turn controls xenobiotic and endogenous steroid hormone metabolism. Steroids nuclear receptor subfamily 1 group I member 2 Homo sapiens