Title : Glutathionylation at Cys-111 induces dissociation of wild type and FALS mutant SOD1 dimers.

Pub. Date : 2011 Aug 16

PMID : 21739997






2 Functional Relationships(s)
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1 Here we examine the effect of Cys-111 glutathionylation, a physiologically prevalent post-translational oxidative modification, on the stabilities of wild type SOD1 and two phenotypically diverse FALS mutants, A4V and I112T. Cysteine superoxide dismutase 1 Homo sapiens
2 Our experimental and computational results show that Cys-111 glutathionylation induces structural rearrangements that modulate stability of both wild type and FALS mutant SOD1. Cysteine superoxide dismutase 1 Homo sapiens