Pub. Date : 2011
PMID : 21734419
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anthracyclines target the enzyme topoisomerase IIalpha (TOP2A). | Anthracyclines | DNA topoisomerase II alpha | Homo sapiens |
| 2 | We set out to perform a retrospective study of the presence of gene abnormalities and the expression of TOP2A in a cohort of breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy. | Anthracyclines | DNA topoisomerase II alpha | Homo sapiens |
| 3 | CONCLUSIONS: TOP2A expression is a marker of the tumor"s proliferation rate and sensitivity to anthracycline-based chemotherapy, and does not depend on the amplification of its gene. | Anthracyclines | DNA topoisomerase II alpha | Homo sapiens |