Title : The mechanism of myeloperoxidase-catalysed oxidation of aminopyrine.

Pub. Date : 1990 Sep

PMID : 2173287






2 Functional Relationships(s)
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1 Compared with the chlorination of monochlorodimedone (MCD), the reaction between aminopyrine and HOCl, produced by the enzymic peroxidation of Cl-, is rate-limiting in the myeloperoxidase-catalysed oxidation of aminopyrine. Hypochlorous Acid myeloperoxidase Homo sapiens
2 The differences in kinetic behaviour between the myeloperoxidase-catalysed chlorination of MCD and oxidation of aminopyrine are explained by the low reactivity of HOCl towards aminopyrine. Hypochlorous Acid myeloperoxidase Homo sapiens